diff --git a/testing/endtoend/deps.bzl b/testing/endtoend/deps.bzl
index 356503c33..5a25c8223 100644
--- a/testing/endtoend/deps.bzl
+++ b/testing/endtoend/deps.bzl
@@ -1,6 +1,6 @@
 load("@bazel_tools//tools/build_defs/repo:http.bzl", "http_archive")  # gazelle:keep
 
-lighthouse_version = "v4.5.0"
+lighthouse_version = "v4.6.0-rc.0"
 lighthouse_archive_name = "lighthouse-%s-x86_64-unknown-linux-gnu-portable.tar.gz" % lighthouse_version
 
 def e2e_deps():
@@ -14,7 +14,7 @@ def e2e_deps():
 
     http_archive(
         name = "lighthouse",
-        sha256 = "1e91ecab827649ac8ea0cfbb11ee2fb159cecd6ac5125e56dd27004225b128c9",
+        integrity = "sha256-9jmQN1AJUyogscUYibFchZMUXH0ZRKofW4oPhAFVRAE=",
         build_file = "@prysm//testing/endtoend:lighthouse.BUILD",
         url = ("https://github.com/sigp/lighthouse/releases/download/%s/" + lighthouse_archive_name) % lighthouse_version,
     )
diff --git a/testing/endtoend/mainnet_e2e_test.go b/testing/endtoend/mainnet_e2e_test.go
index b34a0e7c0..53eeafc07 100644
--- a/testing/endtoend/mainnet_e2e_test.go
+++ b/testing/endtoend/mainnet_e2e_test.go
@@ -10,10 +10,10 @@ import (
 
 // Run mainnet e2e config with the current release validator against latest beacon node.
 func TestEndToEnd_MainnetConfig_ValidatorAtCurrentRelease(t *testing.T) {
-	r := e2eMainnet(t, true, false, types.InitForkCfg(version.Phase0, version.Capella, params.E2EMainnetTestConfig()))
+	r := e2eMainnet(t, true, false, types.InitForkCfg(version.Phase0, version.Deneb, params.E2EMainnetTestConfig()))
 	r.run()
 }
 
 func TestEndToEnd_MainnetConfig_MultiClient(t *testing.T) {
-	e2eMainnet(t, false, true, types.InitForkCfg(version.Phase0, version.Capella, params.E2EMainnetTestConfig()), types.WithValidatorCrossClient()).run()
+	e2eMainnet(t, false, true, types.InitForkCfg(version.Phase0, version.Deneb, params.E2EMainnetTestConfig()), types.WithValidatorCrossClient()).run()
 }
diff --git a/testing/endtoend/mainnet_scenario_e2e_test.go b/testing/endtoend/mainnet_scenario_e2e_test.go
index f2a5892cf..53811089d 100644
--- a/testing/endtoend/mainnet_scenario_e2e_test.go
+++ b/testing/endtoend/mainnet_scenario_e2e_test.go
@@ -9,7 +9,7 @@ import (
 )
 
 func TestEndToEnd_MultiScenarioRun_Multiclient(t *testing.T) {
-	runner := e2eMainnet(t, false, true, types.InitForkCfg(version.Phase0, version.Capella, params.E2EMainnetTestConfig()), types.WithEpochs(24))
+	runner := e2eMainnet(t, false, true, types.InitForkCfg(version.Phase0, version.Deneb, params.E2EMainnetTestConfig()), types.WithEpochs(24))
 	runner.config.Evaluators = scenarioEvalsMulti()
 	runner.config.EvalInterceptor = runner.multiScenarioMulticlient
 	runner.scenarioRunner()